In June 2004, Izabel Goulart made her runway debut, while walking exclusively for Iodice during the prestigious Sao Paulo Fashion Week. Unfortunately, while being on the catwalk, her bikini top fell open causing a stir in Brazilian newspapers. Goulart managed to put this rocky start behind and started building her modeling career as one of the sexiest women of the new millenium.
In 2005, Izabel Goulart walked the Victoria's Secret annual show for the first time and that same year, she became an official Victoria’s Secret Angel. She featured as an Angel between 2005 - 2008, and also walked in the 2008 – 2011 annual shows of the international lingerie label. In addition, the sexy Brazilian appeared on the catwalks of A-list designers, including Balenciaga, Bottega Veneta, Chanel, Valentino, Oscar de la Renta, Michael Kors, Dolce & Gabbana, Stella McCartney and others.
Izabel Goulart's most successful and familiar advertising campaign was for Armani Exchange. Other than that she has featured as one of the faces of Dolce & Gabbana (2011) and was photographed for a DKNY ad campaign (2011).
Apart from modeling, Goulart enjoys lots of philanthropic activities. She puts a lot of effort in assisting local Brazilian hospitals to raise money to provide free insulin for diabetic children in need (Goulart's brother suffers from the disease).