Jovovich made her debut appearance on the catwalks during the Spring 1996 fashion shows of Marc Jacobs, Miu Miu and Todd Oldham. She continued to strut her perfect physique on the best catwalks the fashion world offers and in 2003 released her own fashion line under the name – Jovovich-Hawk. In 2005, she launched the Jovovich-Hawk showroom in Greenwich Village.
During her modeling career, Jovovich was photographed for many ad campaigns both for fashion and for cosmetics labels. She appeared on printed ads for Revlon (1989), Gap (1995), Banana Republic (1997), Versace (1999), Etro (2006) and many others. In addition Jovovich was chosen to be the face of Emporio Armani (2004), Ann Taylor (2010) and also featured as the spokesperson of L'Oreal (1998) and Mango (2006)
Apart from being a successful model, Jovovich is also an actress and a musician. She appeared in several successful motion pictures, including “The Fifth Element” (1997) and “Resident Evil” (2002). She released her first musical album - “The Divine Comedy” - in 1994.