Sean O'Pry first walked as a professional model in 2007, when he opened the Yves Saint Laurent show in Paris. The same season, he also walked for Diesel, Lacoste, Marc by Marc Jacobs, Narciso Rodriguez, and Zenga at New York Fashion Week. This was the season that earned O'Pry worldwide acclaim and resulted in him working for top designers and brands in the future, such as Salvatore Ferragamo, Emporio Armani, Roberto Cavalli, Perry Ellis, and many more.
O'Pry's unique look, sharp cheekbones, and magnetic blue eyes have been captured by some of the world's leading photographers for top advertising campaigns. In 2007, he modeled for Barney's Co-Op and was announced as the new face of Calvin Klein Collection. The following year, O'Pry was chosen to feature as the face of Gianfranco Ferre and was also pictured for Giorgio Armani, Dsquared2, and Belstaff campaigns. In 2010, O'Pry became the face of Bottega Veneta and also featured in the new Calvin Klein Jeans campaign.
When O'Pry is not busy jet-setting around the globe working as a top male model, he likes playing football and lacrosse.